目的 考察交联聚维酮(PVPP)固化肉桂挥发油的适用性。方法 采用交联聚维酮固化肉桂挥发油,以桂皮醛收率为指标,优选交联聚维酮的种类和用量。结果 发现粒径较小的交联聚维酮为固化载体时桂皮醛收率较高,且肉桂挥发油与交联聚维酮最佳固化比例为1∶2,该比例下所制备的固化粉末中桂皮醛的体外溶出速率加快,粉体学性质较好,稳定性提高。结论 交联聚维酮固化挥发油具有广阔的应用前景。
Abstract
OBJECTIVE To study the process of solidifying the volatile oil of Cinnamomum cassia with polyvinylpolypyrrolidone (PVPP). METHODS Volatile oil of Cinnamomum cassia was solidified by PVPP. The variety and amount of PVPP were optimized with the cinnamaldehyde yield as index. The solidification powder was characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The effects of PVPP on the dissolution in vitro and thermal stability of cinnamaldehyde were studied. RESULTS When PVPP with smaller size was used, the cinnamaldehyde yield was higher. The best ratio of drug to PVPP was 1∶2, at which ratio the dissolution rate of cinnamaldehyde increased, the micromeritic properties of the solidification powder was good, and its thermal stability was improved. CONCLUSION Solidifying volatile oils with PVPP has broad application prospects.
关键词
交联聚维酮 /
固化粉末 /
体外溶出 /
热稳定性 /
肉桂挥发油
{{custom_keyword}} /
Key words
solidification powder /
in vitro release /
thermal stability /
Cinnamomum cassia /
volatile oil
{{custom_keyword}} /
中图分类号：
R944
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] DOBROSLAVA B, TEFAN J, TEFAN F.The anti-translocation and anti-inflammatory effect of cinnamon oil in mice with TNBS induced colitis[J].Biologia, 2013,68(5):1000-1003.[2] GHOSH V, SARANYA S, MUKHERJEE A, et al.Cinnamon oil nanoemulsion formulation by ultrasonic emulsification:Investigation of its bactericidal activity[J].J Nanosci Nanotechnol, 2013, 13(1):114-122.[3] ICHIRO K, KATSUTOMO S, YURI T, et al. Antioxidant activity of cinnamon bark oil (Cinnamomum zeylanicum L.)in Japanese quails under thermo neutral and heat stressed conditions[J]. Kafkas Univ Vet Fak,2013,19(5): 889-894.[4] YEH H F, LUO C Y, LIN C Y, et al. Methods for thermal stability enhancement of leaf essential oils and their main constituents from Indigenous Cinnamon (Cinnamomum osmophloeum)[J]. J Agric Food Chem,2013,61(26):6293-6298.[5] LAURA E H, CARMEN G, MATTHEW T, et al.Characterization of beta-cyclodextrin inclusion complexes containing essential oils(trans-cinnamaldehyde,eugenol,cinnamon bark, and clove bud extracts) for antimicrobial delivery applications[J].LWT-Food Sci Technol,2013,51(1): 86-93.[6] XING Y G, XU Q L, ZHANG L, et al. Characteristics and release behavior of microencapsulated cinnamon oil by β-cyclodextrin and chitosan[J].Adv Sci Lett,2012,13(1): 787-790.[7] JIANG Y R, ZHANG Z H, HU S Y, et al. Study on solidifying volatile oil of cinnamon with colloidal silicon dioxide SYLOID244FP[J].China J Chin Mater Med(中国中药杂志), 2013,8(1): 53-56. [8] NING Q, JIANG Y R, ZHANG Z H, et al. Investigation of solidifying volatile oil from cinnamomum cassia with porous starch[J].Chin J Exp Tradit Med Form(中国实验方剂学杂志), 2013,19(3):29-32.[9] DONG Z B, LIANG Y R, FAN F Y, et al. Adsorption behavior of the catechins and caffeine onto polyvinylpolypyrrolidone[J]. J Agric Food Chem,2011,59(8):4238-4247.[10] ZHOU Q T, ARMSTRONG B, LARSON I, et al. Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders[J].Eur J Pharm Sci,2010,40(5):412-421.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金资助项目(81202929)
{{custom_fund}}
PDF(960 KB)
